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Consistently, GSH depletion or silencing of Fe-S cluster-associated GLRXs disrupts mitochondrial redox balance, promotes iron overload, and sensitizes cancer cells to ferroptosis 133,134

5-Amino-1MQ is commonly studied in research settings for its interaction with metabolic pathways, particularly in relation to NNMT (Nicotinamide N-methyltransferase) activity, cellular energy regulation, and adipose tissue function